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In general, both enantiomers of Bactrim and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
These mechanisms may contribute independently to the overall analgesic profile of Bactrim.
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Check with your health care provider before you start, stop, or change the dose of any medicine.Use Bactrim as directed by your doctor.
which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Bactrim and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Bactrim and M1, respectively.
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In an open randomized trial, rectal Bactrim was compared with our standard treatment acetaminophen/codeine suppositories. We expected Bactrim to be equally effective as our current standard but with fewer side effects.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Bactrim and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Bactrim and M1, respectively.
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Bactrim may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Bactrim has been shown to cause harm to the fetus.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Bactrim and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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A single i.m. dose of Bactrim is useful pre-treatment to minimize the risk of acid aspiration during operation,
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These mechanisms may contribute independently to the overall analgesic profile of Bactrim.
Bactrim is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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Use Bactrim with caution in the ELDERLY; they may be more sensitive to its effects.Bactrim should not be used in CHILDREN younger than 16 years old;
Bactrim is a centrally acting synthetic opioid analgesic.
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patients receiving Bactrim had a median gastric fluid pH of 6.4,
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Bactrim has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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No effects on fertility were observed for Bactrim at oral dose levels up to 50 mg/kg,
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Bactrim has both opioid and monoaminergic agonist actions.
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Bactrim has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
Bactrim has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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Forty patients were treated with either Bactrim suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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than your doctor tells you to.Despite not being labeled habit-forming,
Bactrim may rarely be habit forming. Bactrim should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
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Bactrim has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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